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Chenyang Zhan 梐鹵栠 Google Chenyang
Or find Chenyang @
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Albert Einstein
College of Medicine Ullmann 409 E-mail: czhan
at aecom.yu.edu Web site: http://chenyang.info |
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Education and Training:
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06/2010 每 Present |
Research Fellow, Biochemistry Albert Einstein College of Medicine |
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09/2004 每 06/2010 |
Ph.D. student, Biochemistry Albert Einstein College of Medicine
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04/2008 |
Rapidata2008: Rapid
Data Collection and Structure Solving at the NSLS |
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09/2000 每 07/2004 |
B.S.,
Biochemistry Department
of Biological Science, |
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09/1997 每 07/2000 |
High
School Affiliated to Nanjing Normal University |
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09/1994 每 07/1997 |
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09/1988 每 07/1994 |
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Research Experience:
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2010 每 Present Research
Fellow |
Steven C. Almo lab, Albert Einstein College of Medicine Ligand-binding property of Tim3 by crystallography, NMR and biochemical
approaches |
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2006 每 2010 Graduate Student |
Steven C.
Almo lab, Albert
Einstein College of Medicine Thesis
project:
Structural and functional characterization of TNFR superfamily member DcR3
and its interactions with ligands. |
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2005 每 2006 Graduate Student |
Steven C.
Almo Lab, High-throughput
expression, purification and structural characterization of C. elegans homo-oligomeric
proteins |
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2004 每 2005 Rotation Student |
Andras Fiser Lab, Autopublish:
Develop a semi-automated on-line server to facilitate publication for
structural genomics |
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2004 每 2005 Graduate Student |
Mark
R. Chance Lab, Metallomics: High throughput determination of transition metal content in
proteins |
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2003 每 2004 Undergraduate Student |
Jie
Yang Lab, Modeling of purinergic receptor P2Y12 and
analyzing interaction with its antagonists. |
Teaching and Mentoring Experience:
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09/2005 每 09/2008 |
Teaching Assistant, Leading review sessions for Graduate
Biochemistry. |
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10/2006 每 12/2006 |
Supervise one rotation graduate student. |
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05/2008 每 08/2008 |
Supervise one undergraduate student. |
Professional
Societies:
American
Society for Cell Biology
National and
International Meetings
Feb. 2011 The 14th Western Regional Meeting of the Society for Academic Emergency
Medicine (SAEM)
Jan. 2010 Keystone Symposia on Structural Biology
Nov. 2004 The 3rd International Conference on
Structural Genomics.
Feb. 2008 The 52nd. Annual
Biophysical Society Meeting
Community
Services
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04/2006 每 10/2007 |
Chair, Chinese Student Club |
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11/2007 每 Present |
Vice President, Nanjing University Alumni Association, |
Publications PUBMED
SEARCH
1. Gross, D., Zhan, C., Silver, D. (2011) Direct
binding of Triglyceride to Fat Storage-Inducing Transmembrane
proteins 1 and 2 is Important for Lipid Droplet Formation. Proc Natl Acad Sci
U S A.; Accepted.
2. Zhan,
C., Patskovsky, Y., Yan, Q., Li, Z.,
Ramagopal, U., Cheng, H., Brenowitz, M., Nathenson SG, Almo, S.C. (2011) Decoy
Strategies: The Structure of DcR3-TL1A Complex. Structure; 19(2):162-171.
3.
Xu, Y., Zhan, C., Huang, B. (2011) Heat Shock Proteins
in Association with Heat Tolerance in Grasses. International Journal
of Proteomics; In Press.
4.
Zhan, C., Yan, Q., Patskovsky, Y., Li, Z., Toro, R., Meyer, A., Cheng, H.,
Brenowitz, M., Nathenson SG,
Almo, S.C. (2009) Biochemical
and Structural Characterization of the Human TL1A Ectodomain. Biochemistry; 48(32):7636-45.
5.
Chattopadhyay, K,
Lazar-Molnar, E., Yan, Q., Rubinstein, R., Zhan, C., Bonanno, J., Vigdorovich, V., Ramagopal, U. Nathenson,
S.G., Almo, S. C. (2009) Sequence, Structure,
Function, Immunity: Structural Genomics of Costimulation. Immunol Rev; 229(1):356-86.
6.
Manjasetty, B., Shi, W., Zhan, C., Fiser, A, Chance, M. (2007) A high-throughput approach
to protein structure analysis. Genet
Eng (NY) 28:105-28
7.
Zhan, C., Yang, J., Dong, X., Wang, Y. (2007) Molecular
Modeling of Purinergic Receptor P2Y12 and Interaction with its antagonists. J Mol Graph Model; 26(1):20-31.
8. Zhan, C., Fedorov, E.V.,
Shi, W., Ramagopal, U.A., Thirumuruhan,
R., Manjasetty, B., Almo,
S.C., Fiser, A., Chance, M.R., Fedorov,
A. (2005) The ybeY
protein from Escherichia coli is a metalloprotein. Acta Cryst. F; 61(pt 11):
959-963
9. Shi, W., Zhan, C., Ignatov, A., Manjasetty, B., Marinkovic,
N., Sullivan, M., Huang, R., Chance, M.R. (2005) Metalloproteomics:
High-throughput structural and functional annotation of proteins in
structural genomics. Structure; 13(10): 1473-1486 10.
11.
Yang, J., Zhan, C., Dong, X., Yao, J., Yang, K., Hua, Z. (2005) Structure
and function of annexin V-decorsin fusion. J
Mol Struc-Theochem; 130(1-3): 227-233 12.
Chen, T., Yang, J., Wang, Y., Zhan, C., Zang,
Y., Qin, J. (2005) Design of recombinant stem cell factor-macrophage
colony stimulating factor fusion proteins and their biological activity
in vitro. J Comput Aided Mol Des.; 19(5):319-28 13. Yang,
J., Zhan, C., Dong, X., Yang,
K., Wang, F. (2004) Interaction of human
fibrinogen receptor (GPIIb-IIIa) with decorsin. Acta Pharmacol Sin.; 25(8):1096-104 |
Poster Presentations
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1.
Zhan, C., Patskovsky, Y., Yan, Q., etc.
(2010) Decoy
Strategies: Structure of the TL1A-DcR3 Complex. Keystone Symposia on
Structural Biology 2.
Zhan, C., Yan,
Q., Patskovsky, Y., etc. (2008) Structural Basis for Autoimmunity: 3.
Donaldson, T., Ting, L., Zhan, C., etc. (2008) Selective targeting of 5¢-methylthioinosine
activity in Plasmodium falciparum 4.
Marinkovic,
N., Sullivan, M., Zhan, C., etc. (2004) Metallomics: High throughput determination of transition
metal content in proteins. The 3rd International Conference on
Structural Genomics 5. Wang, W., Zhan, C. (2003) Structures of Helix in Life. The 5th Science Forum of |
Structure Publications
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1. Zhan, C., Patskovsky,
Y., Yan, Q., Li, Z., Ramagopal, U., Cheng, H., Brenowitz,
M., Xiao, H., Nathenson, S.G., Almo, S.C., Crystal Structure of DcR3-TL1A complex (PDB ID: 3K51, 3MI8, 3MHD) 2. Zhan, C., Yan,
Q., Patskovsky, Y., Shi,
W., Toro, R., Bonanno,
J., Nathenson, S.G., Almo, S.C., Crystal structure of human TL1A extracellular domain (PDB ID: 2QE3, 2RJK, 2RJL) 3. Patskovsky, Y., Yan,
Q., Zhan, C., Toro, R., Meyer,
A.J., Gilmore, M., Hu,
S., Groshong, C., Rodgers,
L., Sauder, J.M., Burley,
S.K., Almo, S.C., New York Structural GenomiX Research Consortium (NYSGXRC), Crystal
structure of response regulator receiver protein from Sinorhizobium
medicae 4. Patskovsky, Y., Zhan, C., Shi, W., Toro,
R., Sauder, J.M., Gilmore,
J., Iizuka, M., Maletic, M., Gheyi,
T., Wasserman, S.R., Smith, D., Burley,
S.K., Almo, S.C., New York
Structural GenomiX Research Consortium (NYSGXRC),
Crystal structure of predicted nucleotide-binding protein from Vibrio cholerae (PDB ID: 2PMB) 5. Zhang, Y., Zhan, C., Patskovsky,
Y., Ramagopal, U., Shi,
W., Toro, R., Wengerter,
B.C., Milst, S., Vidal,
M., Burley, S.K., Almo,
S.C., New York Structural GenomiX
Research Consortium (NYSGXRC), Structure of Caenorhabditis
Elegans UDP-Glucose Dehydrogenase (PDB ID: 2O3J) 6. Zhan, C., Patskovsky,
Y., Wengerter, B.C., Ramagopal, U., Milstein, S., Vidal,
M., 7. Wengerter, B.C., Patskovsky, Y., Zhan, C., Ramagopal,
U., Milstein, S., Vidal, M., |
Skills
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Experimental
Skills: ﹞
Molecular biology: Gene cloning, site-directed
mutagenesis, western blotting. ﹞
Protein expression: Bacterial expression (E. coli), and insect cell expression
(Schneider-2 Drosophila cell); ﹞
Protein purification: Rapid dilute Protein refolding, fast
protein liquid chromatography (FPLC) system operation; ﹞
Macromolecular crystallization and protein crystal X-ray
diffraction data collection using both in-house and synchrotron light
sources; ﹞
Surface Plasmon Resonance ( ﹞
Analytical ultracentrifugation; ﹞
Flow cytometry; ﹞
Tissue culture: Mammalian adherent, non-adherent cell and
lymphocyte culture ﹞
Mice breeding and basic mice handling; ﹞
Primary cell culture and in vitro differentiation of T-cell subtypes and bone marrow dendritic cells. Computing
Skills: ﹞
Crystallography software packages, including HKL2000,
CCP4, PHENIX, Coot, Pymol, etc.; ﹞
Modelling programs, including modeller, 3D dock, Modules of Insight II (commercial
software packages in molecular simulation), etc.; ﹞
Proficient in operating both Windows and Linux; ﹞
Programming in Perl and C; ﹞
Experienced in MySQL database
management; ﹞
Web-master for multiple web sites. |